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Rationale for the Role of Heparin and Related GAG Antithrombotics in COVID-19 Infection.
Magnani, Harry N.
Clin Appl Thromb Hemost ; 27: 1076029620977702, 2021.
Article in English | MEDLINE | ID: covidwho-1063146

ABSTRACT

The SARS-CoV-2 pandemic has focused attention on prevention, restriction and treatment methods that are acceptable worldwide. This means that they should be simple and inexpensive. This review examines the possible role of glycosaminoglycan (GAG) antithrombotics in the treatment of COVID-19. The pathophysiology of this disease reveals a complex interplay between the hemostatic and immune systems that can be readily disrupted by SARS-CoV-2. Some of the GAG antithrombotics also possess immune-modulatory actions and since they are relatively inexpensive they could play an important role in the management of COVID-19 and its complications.


Subject(s)
COVID-19 Drug Treatment , Fibrinolytic Agents/therapeutic use , Heparin/therapeutic use , Autoantibodies/biosynthesis , COVID-19/complications , COVID-19/physiopathology , Endothelium, Vascular/immunology , Endothelium, Vascular/physiopathology , Endothelium, Vascular/virology , Female , Glycosaminoglycans/therapeutic use , Hemorrhage/etiology , Hemostatic Disorders/drug therapy , Hemostatic Disorders/etiology , Hemostatic Disorders/physiopathology , Humans , Immunologic Factors/therapeutic use , Inflammation/drug therapy , Inflammation/etiology , Inflammation/physiopathology , Male , Pandemics , Risk Factors , SARS-CoV-2/pathogenicity , Thrombin/biosynthesis , Thrombosis/etiology
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